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The McLaren 750S may be more efficient, handle and accelerate better because it weighs about 200 to 300 pounds less than the Ferrari F80.
The 750S is 10.7 inches shorter than the F80, making the 750S easier to handle, maneuver and park in tight spaces.
The 750S is 5.1 inches narrower than the F80, making the 750S easier to handle and maneuver in traffic.
The 750S’ standard power retractable hardtop allows a seamless transition from an open car, to a completely sealed coupe. The F80 doesn’t offer a retractable hardtop.